Targets

May I suggest adding:
%appdata%\Lavasoft\Ad-Aware\Update\*.*
Lavasoft Update Cache folder.  An update to the core definitions is easily 50Mb, these files are not needed once the install is successful, and files in this folder are not cleared out or replaced by Ad-Aware, which can lead to substantial build-up

C:\Program Files\Spybot - Search & Destroy\Updates\*.*
excluding:
downloaded.ini
online.ini
online.ini.uiz

Spyboty Search and destroy Update cache folder.  Someone that doesn't know to look here could find about 50MB of space.  These files are not needed once the extraction is successful, and files in this folder are replaced by Spybot with each update.

Deleting the excluded files above resets the update download list, which makes the updater announce the most recent version of definitions and executables regardless if they have it or not.